The “Thrombophilia Profile-Maxi” is an expansive panel of tests designed to investigate and diagnose diverse thrombophilic conditions, which elevate the risk of abnormal blood clot formation (thrombosis). This profile encompasses a comprehensive array of coagulation and immune-related tests, evaluating different factors integral to the clotting process and immune responses that contribute to thrombotic events. The essential elements of the Thrombophilia Profile-Maxi comprise:

1. Protein C: Evaluates the level and activity of Protein C, a natural anticoagulant regulating blood clotting. Reduced Protein C levels heighten the risk of clot formation.

2. Protein S: Assesses the level and activity of Protein S, another natural anticoagulant collaborating with Protein C. Protein S deficiencies can lead to a prothrombotic state.

3. Antithrombin III (AT-III): Measures the level of AT-III, a critical inhibitor of coagulation factors. Deficiencies in AT-III amplify clotting tendencies.

4. Activated Protein C Resistance (APCR): Tests for resistance to activated protein C, indicating the presence of a genetic mutation linked to an increased clotting risk.

5. Lupus Anticoagulant: Identifies antibodies disrupting the normal clotting process, predisposing to thrombosis.

6. Homocysteine: Measures homocysteine, an amino acid, with elevated levels associated with an increased clotting risk.

7. Beta-2 Glycoprotein 1 (IgG / IgM): Detects antibodies against beta-2 glycoprotein 1, possibly linked to autoimmune-related clotting disorders.

8. ACA (Anticardiolipin Antibodies) (IgG / IgM): Identifies anticardiolipin antibodies associated with autoimmune-mediated clotting events.

The Thrombophilia Profile-Maxi is ordered when there are suspicions of underlying thrombophilia, recurrent blood clots, unexplained thrombotic events, or a family history of thrombosis. This comprehensive assessment aids in the diagnosis and management of thrombophilic conditions, enabling personalized treatment plans to prevent or manage thrombotic events and mitigate complications.